Beau Biden, son of Vice President Joe Biden has died from Brain cancer the White House has confirmed.

Joe Biden’s son, Beau, 46, died from brain cancer on Saturday evening. A statement from the Vice President Joe Biden, read,

“It is with broken hearts that Hallie, Hunter, Ashley, Jill and I announce the passing of our husband, brother and son, Beau, after he battled brain cancer with the same integrity, courage and strength he demonstrated every day of his life…”

Beau Biden was the eldest son of Joe Biden. He was described as an “outspoken supporter of LGBT rights” by Advocate magazine. He had been battling brain cancer for several years.

In April 2013 Biden was a key player along with Delaware Governor Jack Markell in marriage equality legislation and establishing legal protections based on gender identity in Delaware.

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Biden is survived by his wife, Hallie, and two children.

The state of Delaware legalised same-sex marriage on May 7th 2013, with the law going into effect on July 1st, 40 years after the Delaware repealed its sodomy law in July 1973.